In Using Somatic-Cell Hybridization Experiments, a Human Gene Was Found

question 53

Multiple Choice

In using somatic-cell hybridization experiments, a human gene was found to be located on chromosome 6. However, when lod-score analysis was done to detect linkage between this gene and a DNA marker locus also known to be on chromosome 6, no linkage could be found between the marker locus and the gene. What is the MOST likely explanation for this result?

• A) Somatic-cell hybridization experiments are not very accurate, and the gene may be on chromosome 5 or chromosome 7 instead of chromosome 6.
• B) Too few recombinants could be found to indicate linkage in the lod-score analysis.
• C) A lod-score analysis cannot be used when a DNA marker locus needs to mapped with respect to a gene locus.
• D) The gene and the DNA marker locus are so far apart on chromosome 6 that they assort independently.
• E) There were probably too few double-crossover events occurring between the two loci, so the lod score could not be determined accurately.

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Definitions:

Variable Costs

Costs that change in proportion to the level of production or business activity.

Square Feet

A unit of area measurement in the Imperial and U.S. customary measurement systems, commonly used to express the size of a space.

Hydraulic Car Smasher

A heavy-duty machine designed to crush cars into compact sizes using hydraulic pressure for purposes of recycling or disposal.

Marginal Cost

The cost incurred by producing one additional unit of a product or service.