Mutant Forms of Tumor-Suppressor Genes Typically Behave in a Recessive

question 34

Multiple Choice

Mutant forms of tumor-suppressor genes typically behave in a recessive manner. However, a recent study of patients with multiple myeloma revealed that approximately 10% of these patients have one normal p53 gene and one mutant p53 gene. If it is the mutant p53 gene that is responsible for this group's cancer, which of the following statements would most likely be TRUE?

• A) The p53 gene can act in a haploinsufficient manner.
• B) The p53 gene is not a tumor-suppressor gene in these patients but rather an oncogene.
• C) The mutant p53 gene most likely is involved in DNA-repair pathways.
• D) The mutant p53 gene is having epigenetic effects in these patients.
• E) The mutant p53 gene is being overexpressed in these patients.

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