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Identifying an Autosomal Recessive Mutation in a Mutagenic Screen in Drosophila

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Identifying an autosomal recessive mutation in a mutagenic screen in Drosophila requires identification of a mutant in the F3 generation. If testing for a sex- linked recessive lethal mutation (e.g., cn l + using a balancer chromosome such as cnCyO), in which generation can lines with mutations be identified?

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Definitions:

Probability

The measure of the likelihood that an event will occur.

Posterior Probability

The revised probability of an event occurring after taking into consideration new information.

Prior Probability

The probability of an event before new data or information is taken into account.

Conformation

The spatial arrangement of atoms in a molecule that can be altered by rotation around single bonds without breaking chemical bonds.

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