In Order to Identify Genes That Function Together in Genetic

question 7

Multiple Choice

In order to identify genes that function together in genetic pathways researchers can perform modifier screens, looking for second site enhancers or suppressors of a mutant. Which of the following is the most reasonable strategy for carrying out a suppressor screen in particular?

• A) screen for enhancer- trap strains that show gene expression differences in the original mutant.
• B) mutagenize the original mutant and look for new mutations that reduce the severity of the original mutant phenotype
• C) isolate mutants with phenotypes similar to the original mutant phenotype and then cross the mutants to identify the affected gene(s)
• D) identify mutations that, when crossed with the original mutant, result in synthetic lethality
• E) analyze the DNA sequence near the mutation of interest, looking for sequences that may act as silencers

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