Explain How Retinoblastoma Appears Dominant in Pedigrees, When in Fact

question 26

Essay

Explain how retinoblastoma appears dominant in pedigrees, when in fact the mutations underlying this cancer are recessive.

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Definitions:

Semaphorins

Class of chemorepulsive molecules that deflect axons from inappropriate regions.

Rett Syndrome

A rare genetic neurological disorder that primarily affects females, characterized by slow growth, intellectual disability, and motor skill problems.

Asperger Syndrome

A developmental disorder affecting ability to effectively socialize and communicate.

Savant Syndrome

A condition where an individual, often with significant mental disabilities, demonstrates profound and prodigious capacities or abilities in a specific area.