Why Should Lithium Diisopropylamide (LDA) Be Used in Enolate Alkylation

question 67

Multiple Choice

Why should lithium diisopropylamide (LDA) be used in enolate alkylation reactions?

• A)LDA completely converts one equivalent of carbonyl to enolate.
• B)LDA is too bulky to act as a nucleophile.
• C)Lithium complexation with the enolate oxygen can reduce O-alkylation.
• D)LDA will selectively remove the least hindered protons from the carbonyl.
• E)All these reasons are valid.

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