If Patients with Advanced Chronic Myelogenous Leukemia Were Initially Treated

question 12

Multiple Choice

If patients with advanced chronic myelogenous leukemia were initially treated with Gleevec, they eventually develop resistance to the drug. What seems to cause the resistance?

• A)mutations in the BCR portion of the fusion gene
• B)mutations in the ABL portion of the fusion gene
• C)ABL gene deletion
• D)ABL gene amplification
• E)BCR gene amplification

---

Definitions:

Childish Manner

Behavior characterized by a lack of maturity, often associated with silliness, impulsivity, or dependency traits seen in children.

Defense Mechanism

Mental tactics employed by people to deal with real-life situations and preserve their sense of self.

Regression

A return to earlier stages of development in behavior, thought, or emotional functioning, often as a response to stress or trauma.

Juvenile Behavior

Actions or conduct typical of younger individuals or adolescents, often characterized by immaturity or inexperience.