Garrod Hypothesized That "Inborn Errors of Metabolism" Such as Alkaptonuria

question 34

Multiple Choice

Garrod hypothesized that "inborn errors of metabolism" such as alkaptonuria occur because

• A) metabolic enzymes require vitamin cofactors, and affected individuals have significant nutritional deficiencies.
• B) enzymes are made of DNA, and affected individuals lack DNA polymerase.
• C) many metabolic enzymes use DNA as a cofactor, and affected individuals have mutations that prevent their enzymes from interacting efficiently with DNA.
• D) certain metabolic reactions are carried out by ribozymes, and affected individuals lack key splicing factors.
• E) genes dictate the production of specific enzymes, and affected individuals have genetic defects that cause them to lack certain enzymes.

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