Given What You Understand About Inflammation, Why Do You Think

question 5

Multiple Choice

Given what you understand about inflammation, why do you think a person with LAD experiences neutrophilia (high numbers of neutrophils in the blood) ?

• A) When a person has an infection, their number of neutrophils increases. In a person with LAD, the neutrophils do not attach to endothelial cells, and thus cannot not leave the blood vessel to enter infected tissue. As a result, they accumulate in the blood.
• B) The inflammation response in a person with LAD is overactive. They produce an excess of phagocytic cells such as neutrophils and although some of these cells migrate into infected tissue, there are so many of these cells that the rest accumulate in the blood.
• C) In a person with LAD, the neutrophils become "sticky" and adhere strongly to blood vessel walls. At the same time, endothelial cell junctions always tighten during inflammation, so the neutrophils cannot not leave the blood vessel and they accumulate in the blood.
• D) When a person has an infection, their number of neutrophils always decreases significantly. In a person with LAD, there are so few neutrophils that these cells do not leave the blood vessel to enter infected tissue. As a result, they accumulate in the blood.
• E) None of these explains why a person with LAD suffers from neutrophilia.

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