What Is the Most Likely Explanation for a Set of Unaffected

question 3

Multiple Choice

What is the most likely explanation for a set of unaffected parents having two children with a highly-penetrant, autosomal dominant disorder?

• A) Two new mutations occurred in the same gene
• B) Germline mosaicism in one of the parents
• C) Variable expressivity
• D) Somatic reversion in carrier parent
• E) Inactivation of mutant allele in carrier parent

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