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The calculation (New - Old) /Old would be used primarily in:
-pnea
A suffix used in medical terms to denote a condition related to breathing, such as apnea (absence of breathing) or dyspnea (difficulty breathing).
Prefix
A group of letters placed at the beginning of a word to alter its meaning or create a new word, such as “un-” in “unhappy”.
-rrhea
A suffix used in medical terminology indicating a flow or discharge of a particular substance.
-pathy
A suffix used in medical terminology to denote a disorder or disease of a specified type or location.
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