A Loss of Function of Apaf1, the Human Homologue of Ced-4

question 24

Multiple Choice

A loss of function of Apaf1, the human homologue of ced-4 in nematodes, is most likely to result in which of the following?

• A) activation of a developmental pathway found in the nematode but not in humans
• B) a form of cancer in which normal apoptosis fails
• C) excess activation of the human analog of the ced-3 protease
• D) extensive tissue damage due to excess apoptosis

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Definitions:

Overhead

Refers to the ongoing business expenses not directly tied to creating a product or service, including rent, utilities, and administrative costs.

Departmental Overhead Rate Method

The departmental overhead rate method is a way of allocating indirect costs to products or services based on the overhead rates of specific departments within an organization, rather than using a single company-wide rate.

Overhead

The total cost of running a business that cannot be directly attributed to the production of goods or services, similar to factory overhead but can apply to non-manufacturing costs.

Overhead Allocation Base

A measure or activity, such as direct labor hours or machine hours, used to assign overhead costs to products or services.