In the Citric Acid Cycle, Succinate Dehydrogenase Catalyzes the Conversion

question 27

Multiple Choice

In the citric acid cycle, succinate dehydrogenase catalyzes the conversion of succinate to fumarate. This reaction is inhibited by malonate, which resembles succinate but cannot be acted upon by succinate dehydrogenase. Increasing the ratio of succinate molecules to those of malonate in the reaction reduces the inhibitory effect of malonate. What role does malonate play with respect to succinate dehydrogenase?

• A) Malonate is a competitive inhibitor.
• B) Malonate blocks the binding of fumarate.
• C) Malonate is a noncompetitive inhibitor.
• D) Malonate is an allosteric regulator.

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