It Has Been Shown That Inhibition of a Key Chromatin

question 57

Multiple Choice

It has been shown that inhibition of a key chromatin remodeling complex known as NuRD, by deleting one of its subunits, can result in a significant increase in the efficiency of reprogramming of somatic cells into pluripotent stem cells. The reprogramming is normally done by the induced expression of a battery of transcription factors in the somatic cells, but is typically not very efficient. Such an observation suggests that the NuRD complex is normally involved in …

• A) erasing the epigenetic memory in somatic cells.
• B) maintaining the epigenetic memory in somatic cells.
• C) preventing DNA replication.
• D) formation of extended loops from chromosome territories.

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