Imagine a Chromosome Translocation Event That Brings a Gene Encoding

question 30

Multiple Choice

Imagine a chromosome translocation event that brings a gene encoding a histone acetyl transferase enzyme from its original chromosomal location to a new one near heterochromatin. Which of the following scenarios is definitely NOT going to happen?

• A) The gene gets silenced due to heterochromatin expansion, leading to the misregulation of gene expression for a number of critical genes.
• B) The translocation event also brings along a chromatin barrier that can prevent heterochromatin expansion into the gene, and there is no phenotypic anomaly.
• C) Since the gene encodes a histone acetyl transferase, it resists heterochromatin expansion by acetylating its own histones.
• D) The level of the gene product decreases due to a position effect, leading to an imbalance in the chromatin state of the cell that results in the activation of programmed cell death.

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Definitions:

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