Consider the Descriptions Below for Three Different LncRNAs, and Determine

question 62

Short Answer

Consider the descriptions below for three different lncRNAs, and determine whether they function in cis (C) or in trans (T). Your answer would be a three-letter string composed of letters C and T only, e.g. CCT.
( ) The tsiX RNA is transcribed from the X-inactivation center in the X chromosome that will not be inactivated. It is antisense with respect to Xist, repressing its transcription and function.
( ) The ANRIL lncRNA is an antisense transcript in a gene cluster expressing inhibitors of cell-cycle proteins. It silences the entire cluster by recruiting heterochromatin proteins of the Polycomb group.
( ) The PTENP1 lncRNA is similar to an mRNA that encodes the protein PTEN, and contains many of the miRNA response elements present in PTEN mRNA; it therefore protects the PTEN mRNA from miRNA-mediated silencing by acting as a decoy.

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Definitions:

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Popular or fashionable jargon used especially among professionals to impress, persuade, or convey specific insider knowledge.

Non-English Speakers

Individuals whose primary language is not English, often facing challenges in environments where English is the dominant language.

Small Groups

Collections of individuals, typically ranging from three to about twelve, who come together for a common purpose.

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