Consider the Descriptions Below for Three Different LncRNAs, and Determine

question 62

Short Answer

Consider the descriptions below for three different lncRNAs, and determine whether they function in cis (C) or in trans (T). Your answer would be a three-letter string composed of letters C and T only, e.g. CCT.
( ) The tsiX RNA is transcribed from the X-inactivation center in the X chromosome that will not be inactivated. It is antisense with respect to Xist, repressing its transcription and function.
( ) The ANRIL lncRNA is an antisense transcript in a gene cluster expressing inhibitors of cell-cycle proteins. It silences the entire cluster by recruiting heterochromatin proteins of the Polycomb group.
( ) The PTENP1 lncRNA is similar to an mRNA that encodes the protein PTEN, and contains many of the miRNA response elements present in PTEN mRNA; it therefore protects the PTEN mRNA from miRNA-mediated silencing by acting as a decoy.

---

Definitions:

Caregiver Role Strain

Emotional and physical stress experienced by caregivers due to the demands of caring for someone.

Symptoms of Depression

Indicators that may include persistent sadness, loss of interest in activities, changes in appetite or weight, sleep disturbances, and feelings of worthlessness.

Older Adult

An individual who is typically defined as being in the later part of life, often considered to be ages 65 and older.

Life Expectancy

The average period that a person or organism is expected to live, based on factors such as gender, age, health conditions, and lifestyle.