Considering the Following Hydropathy Plot for a Multipass Transmembrane Protein

question 2

Multiple Choice

Considering the following hydropathy plot for a multipass transmembrane protein in the plasma membrane, are the protein termini expected to be located inside (I) or outside (O) of the cell? Which of the regions indicated as 2 and 3 in the plot is expected to have more positively charged residues? The position of positively charged residues near the first transmembrane helix is indicated by an asterisk on the plot.

• A) I; 2
• B) I; 3
• C) O; 2
• D) O; 3

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Definitions:

Impairment Loss

A charge recognized when the carrying amount of an asset exceeds its recoverable amount, reflecting a permanent reduction in the asset's value.

Accumulated Depreciation

The total depreciation that has been recorded against an asset over its useful life, representing the reduction in value of the asset.

Cost Model

An accounting method that values an asset based on its historical cost less any accumulated depreciation and impairment losses.

Accumulated Depreciation

The total amount of depreciation expense that has been recorded against a fixed asset since it was put into use.