Dynamitin Is a Subunit of the Dynactin Complex

question 18

Multiple Choice

Dynamitin is a subunit of the dynactin complex. Its overexpression leads to the disassembly of the complex, and it is therefore considered a dynactin inhibitor. Which of the following processes would happen if dynamitin is overexpressed in a cell?

• A) The motile cilia (if any) would stop beating because the axonemal dyneins could not attach to their neighboring microtubules.
• B) The Golgi apparatus would fragment and become dispersed because the cytoplasmic dyneins could not associate with the Golgi membranes.
• C) The endoplasmic reticulum would collapse because it could not recruit enough kinesins.
• D) The nuclear envelope would disintegrate because the nuclear lamins could not interact with the cytoplasmic cytoskeleton.
• E) The cortex would lose its integrity because the Arp 2/3 complex would also be inhibited.

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