If Cells That Have Started Mitosis Are Treated with Nocodazole

question 55

Multiple Choice

If cells that have started mitosis are treated with nocodazole, a drug that depolymerizes microtubules, what would you expect to happen? Where would you expect Mad2 protein to be localized?

• A) The cells would arrest in prometaphase; Mad2 would be localized to the spindle poles.
• B) The cells would arrest in telophase; Mad2 would be localized to the spindle poles.
• C) The cells would immediately enter anaphase, finish mitosis, and enter G₁; Mad2 would be localized to the spindle poles.
• D) The cells would arrest in prometaphase; Mad2 would be localized to almost all kinetochores.
• E) The cells would arrest in telophase; Mad2 would be localized to almost all kinetochores.

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Definitions:

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