Soon After the Discovery of Nerve Growth Factor (NGF), Researchers

question 2

Multiple Choice

Soon after the discovery of nerve growth factor (NGF) , researchers injected newborn mice with rabbit antiserum (i.e. serum that contains antibodies) against NGF. They observed massive nerve cell death compared to appropriate control injections. Up to 99% of the neurons in some parts of the developing peripheral nervous system died after about a week of daily injections. These results suggest that ...

• A) NGF signaling sensitizes developing nerve cells to apoptotic signals.
• B) developing neurons undergo apoptosis in the presence of rabbit proteins.
• C) developing neurons require NGF for apoptosis.
• D) developing neurons undergo cell death in the absence of NGF.
• E) NGF signaling is sufficient for survival of the developing neurons.

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Definitions:

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