A 15-Year-Old Boy Is Found to Have Unexplained Erythrocytosis on Routine

question 152

Multiple Choice

A 15-year-old boy is found to have unexplained erythrocytosis on routine laboratory analysis.  Evaluation of his immediate family shows that his father and sister also have elevated red cell levels.  Genetic sequencing of the β-globin gene is performed in the affected family members.  The results show a single base substitution at amino acid position 82 that replaces the normal lysine residue with methionine.  Further analysis shows that this amino acid replacement impairs the ionic interaction between the β-subunit and 2,3-bisphosphoglycerate.  As a result of this mutation, the patient's hemoglobin will be most similar to which of the following hemoglobin types?

• A)Hemoglobin A_1c
• B)Hemoglobin C
• C)Hemoglobin F
• D)Hemoglobin H
• E)Hemoglobin S

Understand the importance and impact of interest rates on credit.

Learn about the impact of credit on the economy.

Recognize the specific vulnerabilities different groups of people have towards credit misuse.

Understand the legal framework surrounding consumer credit and rights.

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Definitions:

Independence

The state or quality of being self-reliant and free from external control or support.

On Demand

A service or system that provides goods, services, or media available to consumers as soon as they request it, often via digital means.

Physiological Impact

The effect or change on the physical and biological functions of a body as a result of various factors, including stress, environment, or disease.

Colic

A condition characterized by episodes of significant distress or crying in a healthy baby with no apparent cause.