A 2-Year-Old Boy Is Evaluated for Easy Bruising

question 74

Multiple Choice

A 2-year-old boy is evaluated for easy bruising.  His parents report that he develops marked bruising and open wounds following minor trauma.  The skin is difficult to suture due to its extreme fragility.  Physical examination reveals hyperextensible skin, multiple ecchymoses over the forearms and pretibial regions, and an umbilical hernia.  A skin biopsy is performed, and histochemical evaluation of the biopsy reveals a defect in extracellular processing of collagen.  Which of the following steps of collagen synthesis is most likely impaired in this patient?

• A)Glycosylation of hydroxylysine residues
• B)Interchain C-terminal disulfide bond formation
• C)N-terminal propeptide removal
• D)Proline residue hydroxylation
• E)Triple helix formation

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Definitions:

Generativity

A stage in Erik Erikson's theory of psychosocial development, usually occurring in middle adulthood, where individuals seek to guide the next generation or contribute to society.

Erikson

Refers to Erik Erikson, a developmental psychologist known for his theory on the psychosocial development of humans.

Nonmarital Relationship

A romantic or sexual relationship between individuals who are not legally married to one another.

LAT

Living Apart Together, a relationship in which two people are in a committed relationship but choose to live separately.