A Group of Psychiatrists Conducts a Double-Blind Placebo-Controlled Randomized Trial to Determine

question 94

Multiple Choice

A group of psychiatrists conducts a double-blind placebo-controlled randomized trial to determine the efficacy and safety of cariprazine for the treatment of depressive episodes associated with bipolar I disorder (bipolar depression) in adults.  The treatment response rate was 46% for cariprazine versus 32% for placebo, and the rate for all adverse events was 7% for cariprazine versus 5% for placebo.  The differences in rates were statistically significant.  Which of the following is the approximate number of patients who must be exposed to cariprazine to cause harm to 1 person who otherwise would not have been harmed?

• A)2
• B)8
• C)14
• D)21
• E)50

---

Definitions:

Nonexistent

Indicates something that does not exist or is not present in any form or context.

Blood Pressure Increase

A rise in the force exerted by circulating blood on the walls of blood vessels, often indicating hypertension or other health conditions.

Emotion-Focused Coping

A strategy to manage stress by addressing and modulating one's emotional response to a problem rather than confronting the problem itself.

Pets

Domesticated animals kept for companionship or pleasure rather than for work or food.