Researchers Are Developing an Enzyme-Linked Immunosorbent Assay Test for Diagnosing

question 49

Multiple Choice

Researchers are developing an enzyme-linked immunosorbent assay test for diagnosing rheumatoid arthritis.  The test is designed to detect the presence of serum antibodies against citrullinated proteins.  Two test populations with a differing prevalence of rheumatoid arthritis are selected.  The researchers plan to assess the test's performance in the 2 populations by comparing a number of diagnostic test parameters.  Which of the following performance measures is most likely to be different between the 2 test populations?

• A)Negative likelihood ratio
• B)Positive likelihood ratio
• C)Positive predictive value
• D)Sensitivity
• E)Specificity

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Definitions:

Collagen

A major structural protein found in skin, bone, tendons, and other connective tissues, providing strength and elasticity.

Capillaries

The smallest blood vessels in the body, where the exchange of water, oxygen, carbon dioxide, and many other nutrient and waste substances occurs between blood and surrounding tissues.

Simple Squamous Epithelium

A type of epithelial tissue consisting of a single layer of flat cells that facilitates diffusion and filtration in sites such as the alveoli of the lungs and the glomeruli of the kidneys.

Mucous Glands

Exocrine glands found in various locations of the body that secrete mucus, aiding in lubrication and protection of tissues.