A Case-Control Study Was Conducted to Estimate the Association Between

question 1

Multiple Choice

A case-control study was conducted to estimate the association between simvastatin therapy and serum levels of fibrinogen in patients who underwent percutaneous coronary intervention.  Cases were identified as patients who underwent percutaneous coronary intervention and had high periprocedural levels of fibrinogen (>400 mg/dL) , and controls were identified as patients who underwent percutaneous coronary interventions but had normal levels of fibrinogen (200-400 mg/dL) .  History of simvastatin therapy use was assessed through chart review for every patient.  The number of patients corresponding to each classification criteria is given in the table below. Which of the following is the best statistical method to estimate the association between simvastatin use and high serum fibrinogen levels in this study?

• A)Analysis of variance
• B)Chi-square test
• C)Correlation analysis
• D)Meta-analysis
• E)Two-sample t-test

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Definitions:

Water

A ubiquitous chemical substance composed of hydrogen and oxygen, essential for all known forms of life and used in a wide range of industrial processes.

Interstitial Fluid

The fluid that fills the spaces between cells in tissues, serving as a means of transporting nutrients and wastes.

Blood Plasma

The liquid component of blood that carries cells and proteins throughout the body, comprising about 55% of total blood volume.

Cells

The basic structural, functional, and biological units of all living organisms, serving as the building blocks of life.