A 20-Year-Old Man Suddenly Collapses While Walking on a College

question 82

Multiple Choice

A 20-year-old man suddenly collapses while walking on a college campus.  He is found to be unresponsive and pulseless by a bystander.  Despite efforts by emergency medical personnel, the man is unable to be resuscitated.  His friends say he appeared fatigued and described palpitations and dyspnea with exertion in the weeks leading up to the event.  He had no known medical history and did not use tobacco, alcohol, or illicit drugs.  The man's 3 younger siblings are healthy.  His parents confirm a history of "early heart disease" in a paternal grandfather and request an autopsy and genetic testing for further evaluation.  Genetic studies reveal a defect in a TTN gene exon resulting in a truncated titin protein.  Autopsy findings are most likely to show which of the following phenotypes?

• A)Arrhythmogenic right ventricular cardiomyopathy
• B)Bicuspid aortic valve
• C)Dilated cardiomyopathy
• D)Hypertrophic cardiomyopathy
• E)Restrictive cardiomyopathy

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