A 50-Year-Old Previously Healthy Man Is Evaluated for Progressive Fatigue

question 86

Multiple Choice

A 50-year-old previously healthy man is evaluated for progressive fatigue, weakness, and recurrent gingival bleeding.  Laboratory studies reveal normocytic normochromic anemia, thrombocytopenia, and leukocytosis with circulating myeloblasts.  Bone marrow biopsy establishes a diagnosis of acute myeloid leukemia.  Induction chemotherapy followed by allogeneic hematopoietic cell transplantation (HCT) is planned.  Molecular typing of human leukocyte antigen (HLA) -A, -B, -C, -DP, -DQ, and -DR is performed.  The patient's biological sister, with whom he shares both parents, is eligible for stem cell donation and undergoes HLA typing.  Which of the following is the most likely probability that the sibling will be an identical HLA match with this patient?

• A)0
• B)1/16
• C)1/8
• D)1/4
• E)1/2

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Definitions:

Cognitive Dissonance

The mental discomfort experienced by an individual who holds contradictory beliefs, ideas, or values, leading to an internal conflict.

Purchase Anxiety

The apprehension or doubt a consumer may feel before making a purchase decision, often due to fear of making the wrong choice.

Consumer Cynicism

A sentiment or attitude of distrust towards marketing practices, where consumers doubt the honesty or integrity of advertisements and promotions.

Subliminal Perception

The process by which individuals respond to stimulus that they are not consciously aware of, influencing their behavior or thought process unknowingly.