A 12-Year-Old Boy Is Evaluated in the Clinic Due to Excessive

question 5

Multiple Choice

A 12-year-old boy is evaluated in the clinic due to excessive bleeding following a tooth extraction.  The patient also develops large bruises after only minor injury but has had no major bleeding episodes in the past.  His maternal uncle died from an intracranial hemorrhage.  Laboratory testing reveals decreased coagulation factor VIII activity levels.  A referral is made to a clinical geneticist, who suspects that the patient has a deletion mutation in the enhancer sequence of the factor VIII gene.  This mutation has resulted in decreased transcription of factor VIII by RNA polymerase II.  Which of the following is the most accurate statement regarding the abnormal genetic sequence in this patient?

• A)It can be located upstream, downstream, or within introns of the gene
• B)It can function within only a short distance of the gene
• C)It directly binds RNA polymerase and general transcription factors
• D)It does not require protein binding to affect transcription
• E)It is required to initiate transcription

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Definitions:

Special-Interest Effect

Any political outcome in which a small group (“special interest”) gains substantially at the expense of a much larger number of persons who each individually suffers a small loss.

Government Policy

refers to the actions taken by a government to address issues or achieve goals, which may involve regulations, laws, or spending priorities.

Economic Efficiency

A situation where resources are allocated in a way that maximizes the production of goods and services.

Majority Voting

A decision-making process whereby a decision is made based on the preference of more than half of the members voting.