A 56-Year-Old Woman with a History of Heart Failure Is

question 25

Multiple Choice

A 56-year-old woman with a history of heart failure is admitted to the hospital for orthotopic cardiac transplantation.  The patient developed biventricular failure due to idiopathic myocarditis.  She has had persistent New York Heart Association class IV symptoms refractory to maximal medical therapy and was placed on the transplant waiting list.  An ABO-compatible cadaveric heart is available for transplant with partial human leukocyte antigen (HLA) mismatch.  Cardiac transplantation is performed and the patient's T lymphocytes quickly recognize the foreign HLA molecules of the transplant cells.  Inhibition of which of the following substances would specifically reduce the proliferation and differentiation of these T lymphocytes?

• A)Bcl-2
• B)Calcineurin
• C)E-cadherin
• D)Neurofibromin
• E)p53

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Definitions:

Stressor Predispositions

An individual's inherent susceptibility or inclination to react to stressful environmental situations.

Generativity

A concern for establishing and guiding the next generation, commonly expressed during middle adulthood.

Well-Being

Well-Being is the state of being comfortable, healthy, or happy, reflecting the overall quality of an individual's life.

Work Settings

The environment or context within which job duties are performed, including physical locations and organizational cultures.