An 8-Year-Old Boy Comes to the Office Due to a Mass

question 372

Multiple Choice

An 8-year-old boy comes to the office due to a mass in the right mandible.  His family first noticed it a few months ago, and it has grown rapidly.  He has had no fevers, chills, cough, or weight loss.  The patient and his family recently immigrated to the United States from East Africa.  He has no known medical problems.  Temperature is 37 C (98.6 F) .  Physical examination shows a large tumor on the right mandible with palpable regional lymphadenopathy.  A biopsy of the lesion is performed.  Histopathologic examination shows a diffuse infiltrate of lymphoid cells with numerous mitotic figures; interspersed macrophages with clear cytoplasm are also seen.  These lymphoid cells most likely have a chromosomal translocation that directly alters which of the following processes?

• A)Apoptosis inhibition
• B)DNA repair
• C)Regulation of G1 to S-phase transition
• D)Transcription activation
• E)Tyrosine kinase upregulation

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Definitions:

Psychopathology

The examination of psychological disorders, which encompasses their manifestations, origins, and remedies.

Multiple Disorders

The co-occurrence of two or more disorders or illnesses in the same individual, often complicating diagnosis and treatment.

Unified Protocol

A type of cognitive-behavioral therapy that's transdiagnostic, designed to treat a range of emotional disorders by targeting common underlying factors.

David Barlow

An influential psychologist known for his research and contributions to the understanding and treatment of anxiety disorders.