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A Researcher Is Studying Autopsy Findings in Patients Diagnosed with Neurodegenerative

question 455

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A researcher is studying autopsy findings in patients diagnosed with neurodegenerative disorders.  In some of the brain specimens, a neuronal protein that primarily exists in an alpha-helical secondary structure is found to be in a beta-sheet conformation.  The altered protein is resistant to protease and has accumulated in large quantities within the cells.  Further investigation shows that the abnormal isoform can perpetually induce the same conformational change within normally folded proteins.  Which of the following histopathological changes are most likely present in the brains of these patients?

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Definitions:

Michel Foucault

was a French philosopher and social theorist known for his critical studies of institutions such as prisons, schools, and hospitals, and his theories on power, knowledge, and discourse.

Genealogy of Power

An analytical concept, often associated with Michel Foucault, that examines the history and evolution of how power has been exercised and legitimized.

Michel Foucault

An influential 20th-century French theorist who explored the relationship between power, knowledge, and social practices, emphasizing the role each plays in shaping human behavior and societal institutions.

Discourse

Written or spoken communication, especially within a specific field of study or context, shaping knowledge and societal norms.

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