A Group of Investigators Is Studying Osteoprotegerin Function in Patients

question 197

Multiple Choice

A group of investigators is studying osteoprotegerin function in patients with postmenopausal osteoporosis.  Using an engineered mouse strain, they develop a chimeric monoclonal antibody that blocks binding of receptor activator of nuclear factor kappa B (RANK) to RANK ligand (RANK-L) .  The investigators inject this monoclonal antibody into human subjects.  Eight weeks later, a bone biopsy is obtained from all subjects.  Which of the following is the most likely observed finding?

• A)Decreased bone mineralization
• B)Decreased bone resorption
• C)Increased osteoblast activity
• D)Increased osteoclast activity
• E)Increased survival of osteocytes

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Definitions:

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A mental health disorder characterized by chronic and excessive worry about various aspects of life, often to the extent that it interferes with daily activities.

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A mental health condition triggered by experiencing or witnessing a traumatic event, characterized by flashbacks, nightmares, and severe anxiety.

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A mental health disorder characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions).

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