A 34-Year-Old Man Is Found to Have Dyslipidemia

question 301

Multiple Choice

A 34-year-old man is found to have dyslipidemia.  His other medical problems include a myocardial infarction 1 week ago.  His father died of myocardial infarction at the age of 48 years.  Several other family members have had myocardial infarctions and hypertension.  The patient smoked cigarettes and drank alcohol occasionally but quit after his myocardial infarction.  He is started on simvastatin and cholestyramine.  Which of the following best describes the independent effects of simvastatin and cholestyramine, respectively, on hepatic cholesterol synthesis?

• A)Increase and increase
• B)Increase and decrease
• C)Decrease and increase
• D)Decrease and decrease
• E)Increase and no change