A Neonate Is Found to Have Increased TSH and Low

question 180

Multiple Choice

A neonate is found to have increased TSH and low thyroxine (T4) on routine screening.  He was born by vaginal delivery to a 32-year-old woman at 39 weeks gestation.  Apgar scores were 8 and 9 at 1 and 5 minutes, respectively.  Physical examination reveals an enlarged thyroid gland in the normal position.  Neck ultrasound confirms thyroid enlargement.  Which of the following is the most likely cause of this patient's findings?

• A)Maternal intake of levothyroxine
• B)Maternal intake of propranolol
• C)Maternal intake of propylthiouracil
• D)Transplacental passage of thyroglobulin
• E)Transplacental passage of TSH receptor-stimulating antibodies

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