A Group of Investigators Is Currently Conducting a Phase I

question 85

Multiple Choice

A group of investigators is currently conducting a phase I clinical trial for a newly developed synthetic opioid that has twice the analgesic capability of morphine.  After oral ingestion of a fixed dose by several volunteers, the plasma concentration of the drug is measured and determined to be subtherapeutic.  Rectal administration of the same dose of the drug shows a plasma concentration well within the therapeutic range, almost double the level measured after oral intake.  Which of the following best accounts for the observed difference in drug concentration following rectal administration when compared to oral administration?

• A)Decreased drug delivery to the liver
• B)Greater blood flow to this region of the intestine
• C)Increased absorption rate of the drug
• D)Larger mucosal surface area
• E)Reduced renal blood flow

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Definitions:

Arachidic Acid

A saturated fatty acid with a 20-carbon chain, found in certain plant oils and the fat components of some animals.

Carbon Atoms

The fundamental building blocks of all organic molecules, characterized by having six protons in their nucleus.

Melting Point

The temperature at which a solid becomes a liquid at atmospheric pressure.

Intermolecular Forces

Forces of attraction or repulsion which act between neighboring particles, such as atoms or molecules, affecting the physical properties of substances.