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A 24-year-old man comes to the emergency department in January due to fever and shortness of breath. A week ago, he developed fever, malaise, muscle aches, and rhinorrhea. The symptoms largely resolved 2 days ago, but this morning the patient began having productive cough of green-yellow sputum, shortness of breath, and pleuritic chest pain. He has had no recent travel or other significant illness. The patient has not received the influenza vaccine. He has a history of type 1 diabetes mellitus and takes insulin.
Temperature is 39.1 C (102.4 F) , blood pressure is 135/67 mm Hg, pulse is 104/min, and respirations are 22/min. Pulse oximetry shows 90% on room air. The patient is ill-appearing and in mild respiratory distress. He coughs frequently during the examination. Lung examination shows bronchial breath sounds and crackles in the right lower lung field.
Leukocyte count is 14,000/mm3 with 82% neutrophils. Chest x-ray shows a dense right lower-lobe consolidation with a small area of lucency and small right-sided pleural effusion. Rapid influenza test is positive.
Which of the following empiric treatments is most appropriate for this patient?
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