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A 65-Year-Old Woman Comes to the Emergency Department Due to Worsening

question 84

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A 65-year-old woman comes to the emergency department due to worsening cough and difficulty breathing.  The patient had similar symptoms a month ago and was found to have right-sided pneumonia.  The symptoms resolved with antibiotic treatment but recurred 2 days ago.  During the previous hospitalization, the patient also reported progressive muscle weakness and fatigue of several months' duration.  She subsequently underwent muscle biopsy, which revealed dermatomyositis; oral prednisone therapy was initiated 2 weeks ago.  She still has significant muscle weakness.  The patient also has had poor oral intake and frequent coughing while eating, and has lost 6.8 kg (15 lb) over the last 3 months.  The patient feels mildly depressed but has had no suicidal ideation.  She is a lifelong nonsmoker and does not drink alcohol.
Temperature is 38.6 C (101.5 F) , blood pressure is 122/78 mm Hg, pulse is 89/min, and respirations are 20/min.  Bronchial breath sounds and rhonchi are present over the right lung base.  Muscle strength is moderately decreased in the proximal muscles.  There is a scaly skin rash over the extensor surfaces of both hands.
Laboratory results are as follows:
A 65-year-old woman comes to the emergency department due to worsening cough and difficulty breathing.  The patient had similar symptoms a month ago and was found to have right-sided pneumonia.  The symptoms resolved with antibiotic treatment but recurred 2 days ago.  During the previous hospitalization, the patient also reported progressive muscle weakness and fatigue of several months' duration.  She subsequently underwent muscle biopsy, which revealed dermatomyositis; oral prednisone therapy was initiated 2 weeks ago.  She still has significant muscle weakness.  The patient also has had poor oral intake and frequent coughing while eating, and has lost 6.8 kg (15 lb)  over the last 3 months.  The patient feels mildly depressed but has had no suicidal ideation.  She is a lifelong nonsmoker and does not drink alcohol. Temperature is 38.6 C (101.5 F) , blood pressure is 122/78 mm Hg, pulse is 89/min, and respirations are 20/min.  Bronchial breath sounds and rhonchi are present over the right lung base.  Muscle strength is moderately decreased in the proximal muscles.  There is a scaly skin rash over the extensor surfaces of both hands. Laboratory results are as follows:   Chest x-ray shows a right lower lobe lung infiltrate. Which of the following is most likely responsible for this patient's pulmonary symptoms? A) Esophageal dysfunction B) Impaired mucociliary clearance C) Mycobacterial infection D) Necrotizing vasculitis E) Nonspecific interstitial pneumonitis Chest x-ray shows a right lower lobe lung infiltrate.
Which of the following is most likely responsible for this patient's pulmonary symptoms?


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