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A 13-Year-Old Girl Is Brought to the Clinic by Her

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A 13-year-old girl is brought to the clinic by her parents due to fatigue.  The patient had been well until 2 months ago, when she began the seventh grade.  She has since felt tired most days, especially after walking to classes.  The patient takes no daily medications and follows a well-balanced diet.  Menarche began at age 12, and menstrual cycles occur at 28-day intervals.  Menses last 6-7 days and are sometimes accompanied by abdominal cramping.  Temperature is 37.2 C (99 F) , blood pressure is 105/70 mm Hg, pulse is 100/min, and respirations are 20/min.  Weight is 46 kg (101.4 lb) , which is at the 50th percentile.  Pupils are equal and reactive.  The conjunctivae are pale.  Oropharyngeal examination shows a few brown macules on the lips and buccal mucosa.  The neck is supple with no thyromegaly or lymphadenopathy.  Cardiopulmonary examination is unremarkable.  The abdomen is soft with a normal liver and spleen size.  Distal pulses are 2+.  Results of a complete blood count are as follows: A 13-year-old girl is brought to the clinic by her parents due to fatigue.  The patient had been well until 2 months ago, when she began the seventh grade.  She has since felt tired most days, especially after walking to classes.  The patient takes no daily medications and follows a well-balanced diet.  Menarche began at age 12, and menstrual cycles occur at 28-day intervals.  Menses last 6-7 days and are sometimes accompanied by abdominal cramping.  Temperature is 37.2 C (99 F) , blood pressure is 105/70 mm Hg, pulse is 100/min, and respirations are 20/min.  Weight is 46 kg (101.4 lb) , which is at the 50th percentile.  Pupils are equal and reactive.  The conjunctivae are pale.  Oropharyngeal examination shows a few brown macules on the lips and buccal mucosa.  The neck is supple with no thyromegaly or lymphadenopathy.  Cardiopulmonary examination is unremarkable.  The abdomen is soft with a normal liver and spleen size.  Distal pulses are 2+.  Results of a complete blood count are as follows:   Which of the following is the best next step in management of this patient? A) ACTH stimulation test B) Bone marrow evaluation C) Iron therapy and oral contraception only D) Lead level E) Upper and lower endoscopy Which of the following is the best next step in management of this patient?


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