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A New, Randomized, Placebo-Controlled Trial Studied the Association Between Treatment

question 855

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A new, randomized, placebo-controlled trial studied the association between treatment with 250,000 IU cholecalciferol for 4 months following hip fracture surgery and incidence of falls.  Results showed that at month 4 after surgery, 7 (6.3%) patients in the treatment group reported >1 falls compared to 23 (21.2%) in the placebo group (p < 0.01) ; there was a relative risk reduction of 70.3%.  Treatment with 250,000 IU cholecalciferol for 4 months costs $100 per patient.  Based on this information, how much would it cost to treat enough patients after hip surgery with 250,000 IU cholecalciferol to prevent >1 falls during the first 4 months of therapy?


Definitions:

Partnership Agreement

A legal document outlining the terms and conditions under which a partnership operates.

Implied Novation

A legal concept where a new contract is assumed to replace an old one due to the actions or situations of the parties involved, without this being explicitly stated.

Actual Novation

The replacement of an existing obligation with a new one, extinguishing the original obligation and creating a new contract with different terms.

Buyout Price

The agreed amount for which an ownership interest in a business can be purchased outright.

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