A 40-Year-Old Man with HIV Comes to the Physician for a Routine

question 1

Multiple Choice

A 40-year-old man with HIV comes to the physician for a routine follow-up examination. He has been nonadherent with his antiretroviral medication regimen for several years. He appears chronically ill and fatigued. CD4+ T-lymphocyte count is 205/mm3. HIV genotypic analysis is performed.  The viral isolates are found to have a mutation in the variable (V3) region of the env gene, which makes the virus capable of infecting T cells with a specific surface receptor, but infection of macrophages is inefficient.  Which of the following antiretroviral medications is most likely to be ineffective in this patient?

• A)Atazanavir
• B)Efavirenz
• C)Enfuvirtide
• D)Maraviroc
• E)Raltegravir
• F)Tenofovir

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