The Effects of Cortisol on Vascular Reactivity Are Studied in a Series

question 378

Multiple Choice

The effects of cortisol on vascular reactivity are studied in a series of experiments in hypophysectomized rats. Their preliminary research demonstrates that administering cortisol by itself does not cause a vascular response. After that, the scientists assess the vascular response to an injection of norepinephrine both with and without a cortisol pretreatment. The graph below displays the outcomes of their experiments. Which of the following pharmacologic principles best describes the effect of cortisol in this experiment?

• A)Additive effect
• B)Alteration in metabolism
• C)Permissiveness
• D)Synergistic effect
• E)Tachyphylaxis

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