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A 40-Year-Old Man with HIV Comes to the Physician for a Routine

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A 40-year-old man with HIV comes to the physician for a routine follow-up examination. He has been nonadherent with his antiretroviral medication regimen for several years. He appears chronically ill and fatigued. CD4+ T-lymphocyte count is 205/mm3. HIV genotypic analysis is performed.  The viral isolates are found to have a mutation in the variable (V3) region of the env gene, which makes the virus capable of infecting T cells with a specific surface receptor, but infection of macrophages is inefficient.  Which of the following antiretroviral medications is most likely to be ineffective in this patient?


Definitions:

Cultural Responsiveness

An approach in which the cultural knowledge, prior experiences, frames of reference, and performance styles of ethnically diverse students are recognized and utilized to make learning more relevant and effective.

Dominant Cultural Perspective

The viewpoint of the majority or prevailing culture in a society, which often sets norms and standards that marginalize other perspectives.

Cultural Deficit Model

A controversial perspective that attributes the lower academic achievements of certain cultural groups to deficiencies in their cultural background.

Symbolic Curriculum

The classroom environment includes bulletin boards, school walls, trade books, and so on, ensuring that images portrayed represent student cultures found within.

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