Describe Genetic Factors That Influence Chronic Kidney Disease

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The Answer is Childhood syndromes involving renal pathology have been linked to specific genes. Alport Syndrome is a rare X-linked dominant disorder that causes progressive hematuric non-immune nephritis characterized ultrastructurally by irregular thickening, thinning, and lamellation of the glomerular basement membrane. The genetic defect produces abnormal synthesis of collagen and other connective tissues.
Autosomal dominant polycystic kidney disease accounts for approximately 10% of all cases of polycystic kidney disease (PKD). Mutations in the PKD-1 gene on chromosome 16 account for 85% of cases, whereas mutations in the PKD-2 gene on chromosome 4 represent the remainder. The genetic defect in PKD causes irregularities in maturation of the epithelial lining of the renal tubules.
Although specific genes have not been identified, there are numerous reports of familial clustering of diabetic nephropathy consistent with genetic predisposition, common environmental factors, or both.

Describe Genetic Factors That Influence Chronic Kidney Disease

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