In the Disorder of Sexual Development Called Androgen-Insensitivity Syndrome (AIS)

question 73

Multiple Choice

In the disorder of sexual development called Androgen-Insensitivity Syndrome (AIS) , the individual has XY chromosomes and develops testes, but what's the problem?

• A) The testes produce testosterone but the cells lack receptors for it, so the individual acquires female secondary sexual characteristics but lacks female internal organs.
• B) The SRY gene functions correctly to maintain the Mullerian ducts but testes do not develop and instead the individual develops internal female organs: a functioning female but with a Y-chromosome.
• C) The SRY gene functions correctly so testes and Wolffian ducts form, but lack of sensitivity to testosterone prevents further development of external male characteristics and internal and external female organs also don't develop.
• D) The SRY gene does not function so ovaries form and produce estrogen, but there is a lack of sensitivity to that so the individual develops as a male, but with ovaries.
• E) The testes produce testosterone but the cells lack receptors for it and so other than testes, neither internal nor external male or female characteristics develop and the individual is essentially sex-less.

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