Using the Table of Classification of Recommendations, Indicate How the Following

question 20

Multiple Choice

Using the table of classification of recommendations, indicate how the following evidence should be graded: On the basis of good evidence, it is concluded that a new treatment cures approximately the same percentage of patients as the standard treatment but has a substantial increase in side effects.
$\text { Classification of Recommendations }$
$\begin{array}{|l|l|l|l|l|}\hline \begin{array}{l}\text { Quality of the } \\\text { Evidence }\end{array} & \begin{array}{l}\text { Net Benefit } \\\text { Substantial }\end{array} & \begin{array}{l}\text { Net Benefit } \\\text { Moderate }\end{array} & \begin{array}{l}\text { Net Benefit } \\\text { Small }\end{array} & \begin{array}{l}\text { Net Benefit } \\\text { Zero/negative }\end{array} \\\hline \text { Good } & \text { A } & \text { B } & \text { C } & \text { D } \\\hline \text { Fair } & \text { B } & \text { B } & \text { C } & \text { D } \\\hline \text { Poor } & \text { I } & \text { I } & \text { I } & \text { I }\\\hline\end{array}$
$\text { Adapted from United States Preventive Services Task Force. }$

• A) Grade A
• B) Grade B
• C) Grade C
• D) Grade D
• E) Grade I

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Definitions:

Codominant

A genetic scenario in which two alleles of a gene are expressed equally in the phenotype of heterozygotes.

Heterozygous Individual

A heterozygous individual possesses two different alleles of a gene for a particular trait, resulting in genetic variation.

Different Alleles

Variations or alternative forms of a gene that can exist at a single locus (position) on a chromosome.

Dominant Allele

An allele that expresses its phenotypic effect even when heterozygous with a recessive allele; it masks the effect of a recessive allele.