Imagine You Want to Study Promoter X, Which Controls Many

question 4

Essay

Imagine you want to study Promoter X, which controls many of the genes in B cells that you believe are important for controlling viral infections.You want to generate a transgenic mouse line with a mutation in this promoter that makes it expressed at low levels.Unfortunately, after all of your work, you learn that your mutation is "embryonic lethal." Describe the strategies/techniques that could be used to circumvent this problem.

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Definitions:

Hemolytic Disease

A condition where an immune response leads to the destruction of red blood cells, often seen in newborns due to blood type incompatibility.

Newborn

Refers to an infant who is within its first month of life outside the womb, a critical period for development and adaptation.

Rh Factor

An antigen found on the surface of red blood cells that can lead to immune reactions during blood transfusion or pregnancy if the donor and recipient or mother and fetus have incompatible Rh types.

ABO Blood Groups

The ABO blood group system is one of the most important blood-type systems in human blood transfusion, comprising four main blood groups: A, B, AB, and O.