How Does Allelic Exclusion Prevent Multiple Heavy-Chain Rearrangements from Occurring

question 1

Multiple Choice

How does allelic exclusion prevent multiple heavy-chain rearrangements from occurring in pre-B cells?

• A)RAG1 and RAG2 are downregulated, and TdT activity is lost so that no additional heavy-chain rearrangements may take place.
• B)RAG1 is upregulated whereas RAG2 and TdT are downregulated to prevent heavy-chain recombination on the second set of chromosomes.
• C)RAG1 and RAG2 induce silencing of the second alleles for V_H-DJ_H rearrangement.
• D)TdT initiates light-chain rearrangement.
• E)TdT releases a cytokine to trigger apoptosis in the pre-B cell.

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