How Do Self-Antigens That Are Specific to Tissues Away from the Thymus

question 34

Multiple Choice

How do self-antigens that are specific to tissues away from the thymus (like insulin or keratin for example) get in the thymus so that developing T cells that react to them can be deleted?

• A)Dendritic cells pick them up in the periphery and carry them to the thymus.
• B)Specialized macrophages in the thymus filter the bloodstream and present antigens found there to developing T cells.
• C)A transcription factor, AIRE, is expressed in thymic medullary epithelial cells, which allows these cells to express proteins normally found in other tissues.
• D)They do not get to the thymus, all tissue-specific T cells are deleted in the periphery.
• E)There are special chaperone proteins that bind to peripheral proteins and carry them to the thymus.

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Definitions:

LIFO Cost Flow

A method of stock valuation where the latest items added to the inventory are the first ones to be sold.

Cost of Goods Sold

The direct expenses tied to the production of goods sold by a company, including material and labor costs.

Net Income

A company's profit amount after all deductions for expenses and taxes from revenue have taken place.

FIFO Cost Flow

An inventory valuation method (First In, First Out) where goods first purchased or produced are sold or used first.