Complement Activation Is Implicated in the Pathogenesis of SLE

question 39

Essay

Complement activation is implicated in the pathogenesis of SLE.However, the incidence of SLE is highly correlated to C4 deficiency.Can you explain this paradox?

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Definitions:

White

A racial classification often used to refer to people of European origin, but can also denote purity or absence of color in different contexts.

Marriage Squeeze

A demographic imbalance in which the number of potential brides does not approximately equal the number of potential grooms within a certain population.

Middle Years

The period of life typically between early adulthood and old age, often considered to be from about age 45 to 65, characterized by stability and reflection on life achievements.

Older Men

Adult males who are significantly advanced in age, often characterized by experience, maturity, and changes in physical and cognitive abilities.